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Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 403-415 doi: 10.1007/s11684-021-0858-1
Keywords: myeloproliferative neoplasms IRF4 IRF8 hydroxyurea essential thrombocythemia
Xin Du,Daobin Zhou
Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 437-443 doi: 10.1007/s11684-016-0472-9
A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patients. Ruxolitinib was given twice a day (bid) at a starting dose of 15 mg (n=25) or 20 mg (n=38) based on a baseline platelet count. About 94.7% of the patients achieved a reduction in spleen size, 27.0% of which exhibited significant reduction (≥35%) at week 24. Significant improvement in debilitating constitutional symptoms, as assessed by MFSAF v2.0, was observed in patients treated with ruxolitinib. Ruxolitinib treatment was generally well tolerated by Chinese patients. Although the treatment was associated with an increase in certain adverse events (AEs) that were established as identified risks (anemia and thrombocytopenia), these AEs were considered manageable in this clinical setting. Ruxolitinib provided substantial reductions in splenomegaly and improvements in symptoms, and was well-tolerated by Chinese patients with MF.
Keywords: JAK ruxolitinib Chinese patients myelofibrosis
LIU Hongxing, TONG Chunrong, CAI Peng, GU Jiangying, LIN Yuehui, TENG Wen, WANG He, ZHANG Ying, ZHU Ping
Frontiers of Medicine 2008, Volume 2, Issue 3, Pages 309-313 doi: 10.1007/s11684-008-0059-1
Keywords: specific amplification essential thrombocythemia Single-tube bi-directional JAK2V617F-positive JAK2V617F
Overlap maximum matching ratio (OMMR): a new measure to evaluate overlaps of essential modules
Xiao-xia ZHANG,Qiang-hua XIAO,Bin LI,Sai HU,Hui-jun XIONG,Bi-hai ZHAO
Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 4, Pages 293-300 doi: 10.1631/FITEE.1400282
Keywords: Protein-protein interaction network Essential protein modules Overlap Overlap maximum matching ratio
A New Way to Study the Three Essential Factors of Forest Fire
Zhao Xianwen
Strategic Study of CAE 2000, Volume 2, Issue 5, Pages 66-71
This thesis took the three essential factors of forest fire (fire source, environment, and litter)
Keywords: forecast of forest fire space remote sensing essential factors of forest fire a new way
Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group
JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong
Frontiers of Medicine 2007, Volume 1, Issue 2, Pages 230-233 doi: 10.1007/s11684-007-0045-z
Keywords: case-control significant difference reaction-restriction fragment C825T polymorphism evidence
Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 227-235 doi: 10.1007/s11684-014-0327-1
Accelerated senescence is important because this process is involved in tumor suppression and has been induced by many chemotherapeutic agents. The platinum-based chemotherapeutic agent cisplatin displays a wide range of antitumor activities. However, the molecular mechanism of cisplatin-induced accelerated senescence in hepatocellular carcinoma (HCC) remains unclear. In the present study, the growth inhibitory effect of cisplatin on HepG2 and SMMC-7721 cells was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cellular senescence was then assessed by β-galactosidase assay. Senescence-related factors, including p53, p21, and p16, were evaluated by quantitative reverse transcription-polymerase chain reaction. Reactive oxygen species (ROS) was analyzed by flow cytometry. Our results revealed that cisplatin reduced the proliferation of HepG2 and SMMC-7721 cells in a dose- and time-dependent manner. Senescent phenotype observed in cisplatin-treated hepatoma cells was dependent on p53 and p21 activation but not on p16 activation. Furthermore, cisplatin-induced accelerated senescence depended on intracellular ROS generation. The ROS scavenger N-acetyl-L-cysteine also significantly suppressed the cisplatin-induced senescence of HepG2 and SMMC-7721 cells. In conclusion, our results revealed a functional link between intracellular ROS generation and cisplatin-induced accelerated senescence, and this link may be used as a potential target of HCC.
Keywords: reactive oxygen species senescence cisplatin hepatocellular carcinoma
Cybersecurity Research—Essential to a Successful Digital Future
Jackie Craig
Engineering 2018, Volume 4, Issue 1, Pages 9-10 doi: 10.1016/j.eng.2018.02.006
Yong G. Peng,Haibo Song,E. Wang,Weipeng Wang,Jin Liu
Frontiers of Medicine 2015, Volume 9, Issue 1, Pages 123-128 doi: 10.1007/s11684-014-0366-7
Guidelines for the intraoperative transesophageal echocardiography (TEE) examination have defined a detailed standard for medical professionals, particularly anesthesiologists, on how a TEE exam should proceed. Over the years, TEE has gained substantial popularity and emerged as a preferred monitoring modality to aid in perioperative management and decision making during hemodynamic instability situations or critical care settings. TEE training pathways and practice guidelines have been well established in western countries and many regions of the world. However, TEE training and practice information for anesthesiologists are lacking in China. As innovative technologies develop, other educational models have emerged to aid in obtaining competency in basic TEE exam. Hence, establishing a consensus on the ideal TEE training approach for anesthesiologists in China is urgently needed. Developing an effective curriculum that can be incorporated into an anesthesiology resident’s overall training is also necessary to provide knowledge and skills toward competency in basic TEE exam. With evolving medical system reforms and increasing demands for intraoperative hemodynamic monitoring to accommodate surgical innovations, anesthesiology professionals are increasingly obliged to perform intraoperative TEE exams in their current and future practices. To overcome obstacles and achieve significant progress in using the TEE modality to help in intraoperative management and surgical decision making, publishing basic TEE training guidelines for China’s anesthesiologists is an important endeavor.
Keywords: transesophageal echocardiography guidelines training competency
Study on Harmony Mechanism of Virtual Enterprise
Wang Shuo,Tang Xiaowo
Strategic Study of CAE 2004, Volume 6, Issue 4, Pages 82-85
In the paper, the operation and development essential factors and present harmony property analysis
Keywords: virtual enterprise harmony mechanism coordination essential factor
is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice
Yuqin Men, Xiujuan Li, Hailong Tu, Aizhen Zhang, Xiaolong Fu, Zhishuo Wang, Yecheng Jin, Congzhe Hou, Tingting Zhang, Sen Zhang, Yichen Zhou, Boqin Li, Jianfeng Li, Xiaoyang Sun, Haibo Wang, Jiangang Gao
Frontiers of Medicine 2019, Volume 13, Issue 6, Pages 690-704 doi: 10.1007/s11684-018-0638-8
Keywords: TPRN stereocilia stereociliary rootlet actin filament CRISPR/Cas9 hearing
A Study on the Essence of Process Manufacturing
Fan Jiongming,Hu Shanying,Chen Dingjiang,Zhang Qun,Li Jin,Ma Shujie,,Song Xiaoxu,Jin Yong,Chen Bingzhen and Yin Ruiyu
Strategic Study of CAE 2017, Volume 19, Issue 3, Pages 80-88 doi: 10.15302/J-SSCAE-2017.03.012
Process manufacturing is an important pillar of China's economic development, and its orderly and healthy development is of great significance to China’s economic and social development. However, the development of process manufacturing is constrained by its enormous consumption of resources and energy and its serious environmental impact. To reach a deeper understanding of the future development of process manufacturing, this study extends an analytical perspective from a single industry to all forms of process manufacturing. Based on the concepts of thermodynamics and entropy, this study analyzes the essence of process manufacturing. Three groups of key factors are used to build the analysis framework: flow and process; material, energy, and information; and scale and efficiency. A chemical engineering process and a phosphorus chemical process are then analyzed using this framework. The results show that the fundamental direction of the development of process manufacturing is to minimize the entropy increments of the whole system, rather than only those of the process system, while ignoring the entropy increments of the system of the external environment. In order to minimize the entropy increments of the whole system, it is necessary not only to pay attention to the economic benefits of the process system, but also to improve resource, energy, and environmental efficiency. To improve efficiency, the technology involved requires improvement, upgrading, and innovation. Improving and upgrading the technology can slightly improve the efficiency of a process system, while revolutionary innovation in the technology may greatly improve the efficiency.
Keywords: process manufacturing entropy process system essence essential characteristic
Amy S. Li, Akimasa Iijima, Junhao Huang, Qing X. Li, Yongli Chen
Engineering 2020, Volume 6, Issue 5, Pages 541-545 doi: 10.1016/j.eng.2019.07.027
Essential oil has been used as sedatives, anticonvulsants, and local anesthetics in traditional medicalcomponents such as methyl eugenol (ME), estragole (EG), and citronellal, are the active chemicals in many essentialConsidering that multiple monoterpenoids are found within the same essential oil, it is likely that LL
Keywords: Essential oil γ-aminobutyric acid type A receptor Linalool Monoterpenoid Nicotinic acetylcholine
A Scenario-Based Evaluation of COVID-19-Related Essential Clinical Resource Demands in China Article
Ting Zhang, Qing Wang, Zhiwei Leng, Yuan Yang, Jin Yang, Fangyuan Chen, Mengmeng Jia, Xingxing Zhang, Weiran Qi, Yunshao Xu, Siya Chen, Peixi Dai, Libing Ma, Luzhao Feng, Weizhong Yang
Engineering 2021, Volume 7, Issue 7, Pages 948-957 doi: 10.1016/j.eng.2021.03.020
Keywords: COVID-19 Transmission dynamics model Clinical resource demands Vaccination
Title Author Date Type Operation
expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essentialthrombocythemia
Journal Article
Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essentialthrombocythemia myelofibrosis in the Chinese population
Xin Du,Daobin Zhou
Journal Article
Observation of a higher JAK2 V617F homozygous mutated clone in polycythemia vera compared to essentialthrombocythemia
LIU Hongxing, TONG Chunrong, CAI Peng, GU Jiangying, LIN Yuehui, TENG Wen, WANG He, ZHANG Ying, ZHU Ping
Journal Article
Overlap maximum matching ratio (OMMR): a new measure to evaluate overlaps of essential modules
Xiao-xia ZHANG,Qiang-hua XIAO,Bin LI,Sai HU,Hui-jun XIONG,Bi-hai ZHAO
Journal Article
Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group
JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong
Journal Article
Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular
Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu
Journal Article
Essential training steps to achieving competency in the basic intraoperative transesophageal echocardiography
Yong G. Peng,Haibo Song,E. Wang,Weipeng Wang,Jin Liu
Journal Article
is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice
Yuqin Men, Xiujuan Li, Hailong Tu, Aizhen Zhang, Xiaolong Fu, Zhishuo Wang, Yecheng Jin, Congzhe Hou, Tingting Zhang, Sen Zhang, Yichen Zhou, Boqin Li, Jianfeng Li, Xiaoyang Sun, Haibo Wang, Jiangang Gao
Journal Article
A Study on the Essence of Process Manufacturing
Fan Jiongming,Hu Shanying,Chen Dingjiang,Zhang Qun,Li Jin,Ma Shujie,,Song Xiaoxu,Jin Yong,Chen Bingzhen and Yin Ruiyu
Journal Article
Putative Mode of Action of the Monoterpenoids Linalool, Methyl Eugenol, Estragole, and Citronellal on Ligand-Gated Ion Channels
Amy S. Li, Akimasa Iijima, Junhao Huang, Qing X. Li, Yongli Chen
Journal Article